Noninvasive detection of cardiac allograft rejection by prospective telemetric monitoring
نویسندگان
چکیده
منابع مشابه
Noninvasive monitoring of mouse renal allograft rejection using micro-CT
PURPOSE Acute renal graft rejection can only be definitively diagnosed by renal biopsy. However, biopsies carry a risk of renal transplant injury and loss. Micro-CT is widely used in preclinical studies of small animals. Here, we propose micro-CT could noninvasively monitor and evaluate renal location and function in a mouse kidney transplant model. METHODS Orthotopic kidney transplantation w...
متن کاملNoninvasive evaluation of cardiac allograft rejection by cellular and functional cardiac magnetic resonance.
OBJECTIVES We sought to use cardiac magnetic resonance (CMR) to establish sensitive and reliable indexes for noninvasive detection of acute cardiac allograft rejection. BACKGROUND Appropriate surveillance for acute allograft rejection is vitally important for graft survival. The current gold standard for diagnosing and staging rejection after organ transplantation is endomyocardial biopsy, wh...
متن کاملNoninvasive diagnosis of cardiac allograft rejection. Another of many searches for the grail.
Survival after cardiac transplantation has improved steadily over the past decade, with mortality at 1 year falling to as low as 10% in many centers. This improvement in survival is owed in part to better, more specific immunosuppressive agents such as cyclosporine and antilymphocyte an-tibodies.'-3 Also, to a large extent survival has improved because of the early diagnosis of rejection by sur...
متن کاملMechanisms of chronic cardiac allograft rejection.
Chronic rejection in the form of cardiac allograft vasculopathy is one of the major factors that affects long-term graft and patient survival after heart transplantation. Whereas multiple factors contribute to the development of cardiac allograft vasculopathy, immunologic mechanisms play the predominant role in the chronic rejection process, because both alloimmune and autoimmune responses are ...
متن کاملAntibody Mediated Rejection of the Cardiac Allograft
Antibody mediated rejection (AMR), also known as B-cell mediated rejection or humoral rejection, of the cardiac allograft was first clinically described in the late 1980’s (Herskowitz et al., 1987) followed shortly thereafter by pathologic evidence to support a unique rejection process apart from cellular mechanisms (Hammond et al., 1989). This is in contrast to the progression of knowledge reg...
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ژورنال
عنوان ژورنال: The Journal of Thoracic and Cardiovascular Surgery
سال: 1992
ISSN: 0022-5223
DOI: 10.1016/s0022-5223(19)34922-0